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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
1962 1
1963 2
1964 1
1965 3
1966 5
1967 9
1968 13
1969 13
1970 19
1971 13
1972 17
1973 19
1974 20
1975 82
1976 104
1977 95
1978 90
1979 101
1980 138
1981 118
1982 138
1983 190
1984 232
1985 237
1986 240
1987 279
1988 363
1989 384
1990 403
1991 469
1992 497
1993 553
1994 572
1995 571
1996 599
1997 642
1998 749
1999 748
2000 806
2001 976
2002 1015
2003 1097
2004 1144
2005 1444
2006 1644
2007 1793
2008 1797
2009 1926
2010 2037
2011 2070
2012 2330
2013 2411
2014 2645
2015 2777
2016 2871
2017 2946
2018 3233
2019 3396
2020 3418
2021 3859
2022 3744
2023 3693
2024 1406

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59,217 results

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Page 1
Biological therapy in systemic lupus erythematosus, antiphospholipid syndrome, and Sjogren's syndrome: evidence- and practice-based guidance.
Marinho A, Delgado Alves J, Fortuna J, Faria R, Almeida I, Alves G, Araújo Correia J, Campar A, Brandão M, Crespo J, Marado D, Matos-Costa J, Oliveira S, Salvador F, Santos L, Silva F, Fernandes M, Vasconcelos C. Marinho A, et al. Front Immunol. 2023 Apr 17;14:1117699. doi: 10.3389/fimmu.2023.1117699. eCollection 2023. Front Immunol. 2023. PMID: 37138867 Free PMC article. Review.
Severe manifestations and refractory/intolerance to conventional immunosuppressants demand other options, namely biological drugs, and small molecules. We aimed to define evidence and practice-based guidance for the off-label use of biologics in SLE, APS, and SS. .. …
Severe manifestations and refractory/intolerance to conventional immunosuppressants demand other options, namely biological drugs, an …
Single-cell Proteomics: Progress and Prospects.
Kelly RT. Kelly RT. Mol Cell Proteomics. 2020 Nov;19(11):1739-1748. doi: 10.1074/mcp.R120.002234. Epub 2020 Aug 26. Mol Cell Proteomics. 2020. PMID: 32847821 Free PMC article. Review.
Single-cell proteomics capabilities have the potential to transform biomedical research and enable understanding of biological systems with a new level of granularity. Recent advances in sample processing, separations and MS instrumentation now make it possible to quantify …
Single-cell proteomics capabilities have the potential to transform biomedical research and enable understanding of biological system …
Relapsing polychondritis: state-of-the-art review with three case presentations.
Grygiel-Górniak B, Tariq H, Mitchell J, Mohammed A, Samborski W. Grygiel-Górniak B, et al. Postgrad Med. 2021 Nov;133(8):953-963. doi: 10.1080/00325481.2021.1979873. Epub 2021 Sep 30. Postgrad Med. 2021. PMID: 34533099 Review.
English was the language of use. Search inputs included 'relapsing polychondritis,' 'polychondritis,' 'relapsing polychondritis symptoms,' and 'treatment of relapsing polychondritis.' ...Acquiring such information will refine the current knowledge of RPC, which will improv …
English was the language of use. Search inputs included 'relapsing polychondritis,' 'polychondritis,' 'relapsing polychondritis sympt …
BepiPred-3.0: Improved B-cell epitope prediction using protein language models.
Clifford JN, Høie MH, Deleuran S, Peters B, Nielsen M, Marcatili P. Clifford JN, et al. Protein Sci. 2022 Dec;31(12):e4497. doi: 10.1002/pro.4497. Protein Sci. 2022. PMID: 36366745 Free PMC article.
In this paper, we present BepiPred-3.0, a sequence-based epitope prediction tool that, by exploiting LM embeddings, greatly improves the prediction accuracy for both linear and conformational epitope prediction on several independent test sets. Furthermore, by carefully selecting …
In this paper, we present BepiPred-3.0, a sequence-based epitope prediction tool that, by exploiting LM embeddings, greatly improves the pre …
2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis.
Angeles-Han ST, Ringold S, Beukelman T, Lovell D, Cuello CA, Becker ML, Colbert RA, Feldman BM, Holland GN, Ferguson PJ, Gewanter H, Guzman J, Horonjeff J, Nigrovic PA, Ombrello MJ, Passo MH, Stoll ML, Rabinovich CE, Sen HN, Schneider R, Halyabar O, Hays K, Shah AA, Sullivan N, Szymanski AM, Turgunbaev M, Turner A, Reston J. Angeles-Han ST, et al. Arthritis Care Res (Hoboken). 2019 Jun;71(6):703-716. doi: 10.1002/acr.23871. Epub 2019 Apr 25. Arthritis Care Res (Hoboken). 2019. PMID: 31021540 Free PMC article.
Regular ophthalmic screening of children with JIA is recommended because of the risk of uveitis, and the frequency of screening should be based on individual risk factors. Regular ophthalmic monitoring of children with uveitis is recommended, and intervals should be based …
Regular ophthalmic screening of children with JIA is recommended because of the risk of uveitis, and the frequency of screening should be ba …
The 5-point Investigator's Global Assessment (IGA) Scale: A modified tool for evaluating plaque psoriasis severity in clinical trials.
Langley RG, Feldman SR, Nyirady J, van de Kerkhof P, Papavassilis C. Langley RG, et al. J Dermatolog Treat. 2015 Feb;26(1):23-31. doi: 10.3109/09546634.2013.865009. Epub 2013 Dec 20. J Dermatolog Treat. 2015. PMID: 24354461 Review.
OBJECTIVE: Characterize a 5-point Investigator's Global Assessment (IGA) tool and evaluate whether it meets the needs for a valid, clinically meaningful measure. METHODS: A 5-point IGA tool was developed with input from regulatory authorities and clinical trial investigato …
OBJECTIVE: Characterize a 5-point Investigator's Global Assessment (IGA) tool and evaluate whether it meets the needs for a valid, clinicall …
Biological factors that impinge on Chagas disease drug development.
Francisco AF, Jayawardhana S, Lewis MD, Taylor MC, Kelly JM. Francisco AF, et al. Parasitology. 2017 Dec;144(14):1871-1880. doi: 10.1017/S0031182017001469. Epub 2017 Aug 23. Parasitology. 2017. PMID: 28831944 Free PMC article. Review.
The urgent need for new therapeutic approaches is being met by a combined effort from the academic and commercial sectors, together with major input from not-for-profit drug development consortia. With the disappointing outcomes of recent clinical trials against chronic Ch …
The urgent need for new therapeutic approaches is being met by a combined effort from the academic and commercial sectors, together with maj …
Input-output relations in biological systems: measurement, information and the Hill equation.
Frank SA. Frank SA. Biol Direct. 2013 Dec 5;8:31. doi: 10.1186/1745-6150-8-31. Biol Direct. 2013. PMID: 24308849 Free PMC article. Review.
Biological systems produce outputs in response to variable inputs. Input-output relations tend to follow a few regular patterns. ...I start with the various processes that could explain the discrepancy between basic chemistry and biological pattern. I …
Biological systems produce outputs in response to variable inputs. Input-output relations tend to follow a few regular …
Biological signal processing filters via engineering allosteric transcription factors.
Groseclose TM, Hersey AN, Huang BD, Realff MJ, Wilson CJ. Groseclose TM, et al. Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2111450118. doi: 10.1073/pnas.2111450118. Proc Natl Acad Sci U S A. 2021. PMID: 34772815 Free PMC article.
Biological signal processing can be achieved by way of allosteric transcription factors. ...In this study, we present a class of engineered allosteric transcription factors capable of processing two-signal INPUTS, such that a sequence of INPUTS …
Biological signal processing can be achieved by way of allosteric transcription factors. ...In this study, we present a class …
59,217 results
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